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What is the hardest eye color to get?

Of those four, green is the rarest. It shows up in about 9% of Americans but only 2% of the world's population. Hazel/amber is the next rarest of these.

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EYE COLOR U.S. POPULATION WORLD POPULATION Gray and other Less than 1% Less than 1% Green 9% 2% Hazel/amber 18% 10% Blue 27% 8% to 10% Brown 45% 55% to 79% There's not much information on gray-colored eyes. In studies, gray and blue have historically been combined. This may change since the American Academy of Ophthalmology (AAO) has separated gray into an "other" category, which it shares with rare eye color differences discussed later in this article.

What Determines Eye Color?

Eye color is influenced by the production of melanin, or pigments, in the iris—the colored part of your eye. More melanin means darker eyes, less means lighter eyes. Different types of melanin determine the specific hue of eyes. Eumelanin is a black-brown pigment responsible for darker eyes, hair, and skin. Pheomelanin is a yellow-red pigment that behind green or amber eyes, red hair, and freckles. People in countries farther away from the equator tend to have lighter-colored eyes and skin. Darker eyes and skin are common in warmer locales, closer to the equator. Of course, all of this comes down to genetics.

Genetics of Eye Color

Scientists used to think that eye color inheritance was a simple matter of whether genes present were dominant (expressed whenever present) or recessive (only expressed when matched with the same gene). In other words, brown eye color (considered dominant) would be expected in a child even if only one parent has brown eyes. Blue eye color (considered recessive) would only be expected in a child with two blue-eye parents. But recent discoveries have shown that the genetics of eye color are more complex than that. Two people with brown eyes, for example, can have a child with lighter eyes. Most eye-color genes have something to do with the transport, production, and storage of melanin. More melanin in the iris makes for brown eyes, while less of it may mean blue, hazel, green, or gray eyes. The amount of melanin present in the front of the iris, the back of the iris, and in the stroma layer between them matters too.

What Genes Determine Your Eye Color?

Multiple genes influence the various combinations and concentrations of melanin. The OCA2 gene plays the most prominent role in determining your eye color. Researchers have identified at least nine other genes involved in the production and distribution of pigments. For example, the HERC2 gene turns the OAC2 gene on and off as needed. Other genes that play a role in eye color include ASIP, IRF4, SLC24A4, SLC24A5, SLC45A2, TPCN2, TYR, and TYRP1. Countless combinations of these genes produce a continuum of eye colors in individuals.

Other Eye Color Differences

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Abnormal eye colors or appearances are rare and fall into the "other" category with gray eyes.

Heterochromia

People with heterochromia have different colored eyes. Some people are born like this. Often there's no known reason for it, but it can be caused by a condition known as piebaldism, a lack of pigment-producing cells in patches of hair, skin, and, in some cases, one eye. You can also develop heterochromia later in life. It can occur due to:

Injury

Eye surgery

Medication, including some glaucoma drugs

Illness, including glaucoma and diabetes

Heterochromia itself doesn't need to be treated. If it's caused by an underlying condition, though, you should get proper treatment for that condition.

Anisocoria

Anisocoria is when someone has two different pupil sizes. The larger the pupil, the more black there is in the center of the eye. This isn't an eye color, but it can make someone look like they have heterochromia. Anisocoria is usually harmless, but it can be a symptom of some serious eye problems. These may include:

Nervous system problems

High stroke risk

Viral infection

Horner syndrome, a rare condition involving drooping eyelids, different-sized pupils, and lack of facial sweat If you have anisocoria along with certain other symptoms, you should see an eye doctor. Watch for symptoms such as:

Dropping eyelids

Difficulty moving your eye

Pain in your eye

Fever

Headache

Reduced sweating

Anisocoria itself doesn't need to be treated, but an underlying condition may need to be. Albinism is low amounts of melanin in the skin, hair, and eyes. In some people, it only affects the eyes. This is called ocular albinism. People with albinism may have lighter versions of standard eye colors. But they may also have eyes that appear:

Red

Violet

The iris doesn't actually have red, pink, or violet pigment, though. These colors result from blood vessels at the back of the eye being visible. In other people, the color of the iris blocks the view of these blood vessels. People with albinism often have serious vision problems. That's because melanin helps the eye develop normally before birth.

Eye Color and Your Health

Having a rare eye color or appearance may seem special and distinctive. It may go beyond appearance, though, as eye color (or shade) may be tied to certain health benefits or concerns. A 2014 study concluded women with light-colored eyes were better able to withstand pain during pregnancy than those with darker eyes. The sample size for this study was relatively small, including just 58 women, but another small study had similar results. A review from 2015 suggests people with darker eyes may have a reduced risk of hearing loss not related to age. However, research from 2011, suggests a link between blue eyes and type 1 diabetes. This work hasn't been replicated, though.

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Lighter eye color is also associated with an increased risk of macular degeneration, which causes a loss of your center field of vision, as well as ocular melanoma (cancer in or around the eye). This is all preliminary work, though. More research is needed to confirm such connections and associations.

Eye Color and Changes With Age

Your eye color can change in adulthood and may take on a more rare appearance. Sometimes, it's not a cause for concern. Other times, it's due to diseases, medication use, or injury and may need treatment. If you don't have gray eyes but they appear to become more gray over time, it may be due to a cataract. This is a clouding of the eye's lens. Cataracts can affect your vision and may need to be surgically removed. Let your eye-care provider know if your eyes appear to be turning gray or milky. Brown freckles can develop in your iris over time, usually due to sun exposure. Most of them are harmless but sometimes they can be cancerous, so bring those to your provider's attention if they occur. Conditions like Fuchs heterochromic iridocyclitis can lighten your eye color and may lead to serious vision problems. Fuchs involves inflammation in some of the structures at the front of your eye. It may cause:

Loss of pigment in your eye, which changes the color

Atrophy (wasting) of the iris

Cataracts

Glaucoma, which can cause loss of vision

It may seem fun or exciting to have your eyes change color. Because of the potential for serious vision problems, though, you should be evaluated by a healthcare provider.

Changing Your Eye Color

If you want to change your eye colored contact lenses are the easiest option. You can have color added to lenses you wear to correct your vision. If you don't need corrective lenses, you can order some that are purely for looks. However, you should still see an eye-care professional and get a prescription for them. The AAO recommends never buying contact lenses that don’t require a prescription due to an increased risk of eye infections.

A Word From Verywell

Eye color is a big part of appearance. Whether it has health effects beyond that is still up for debate. But if your eyes are gray or green, or if you have heterochromia, anisocoria, or albinism, you can confidently say your eyes are rare.

verywellhealth.com - What Is the Rarest Eye Color? - Verywell Health

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